Transcription factor binding dynamics during human ES cell differentiation
نویسندگان
چکیده
منابع مشابه
Transcription factor binding dynamics during human ESC differentiation
Alexander M. Tsankov1,2,3, Hongcang Gu1, Veronika Akopian2,3, Michael J. Ziller1,2,3, Julie Donaghey1,2,3, Ido Amit1,4, Andreas Gnirke1, and Alexander Meissner1,2,3 1Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA 2Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA 3Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachuset...
متن کاملDynamics of GATA transcription factor expression during erythroid differentiation.
Although the formation of terminally differentiated erythroid cells has been shown to require the presence of a functional GATA-1 gene in vivo, the role of this transcription factor and other members of the GATA family at earlier stages of erythroid differentiation is unclear. In this report, the expression of GATA-1, GATA-2, and GATA-3 has been examined in enriched peripheral blood progenitors...
متن کاملLive-Cell Chromosome Dynamics and Outcome of X Chromosome Pairing Events during ES Cell Differentiation
Random X inactivation represents a paradigm for monoallelic gene regulation during early ES cell differentiation. In mice, the choice of X chromosome to inactivate in XX cells is ensured by monoallelic regulation of Xist RNA via its antisense transcription unit Tsix/Xite. Homologous pairing events have been proposed to underlie asymmetric Tsix expression, but direct evidence has been lacking ow...
متن کاملDynamics of Transcription Factor Binding Site Evolution
Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regulatory regions on the DNA is a key regulatory mechanism that determines gene expression and hence heritable phenotypic variation. We use a biophysical model for directional selection on gene expres...
متن کاملTranscription factor binding predicts histone modifications in human cell lines.
Gene expression in higher organisms is thought to be regulated by a complex network of transcription factor binding and chromatin modifications, yet the relative importance of these two factors remains a matter of debate. Here, we show that a computational approach allows surprisingly accurate prediction of histone modifications solely from knowledge of transcription factor binding both at prom...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2015
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature14233